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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2007 January-February;73(1-2):49-56

language: English, Italian

Myocardial necrosis biomarkers after different cardiac surgical operations

Landoni G. 1, Pappalardo F. 1, Calabrò M. G. 1, Boroli F. 1, Sottocorna O. 1, Aletti G. 2, Crescenzi G. 1, Zangrillo A. 1

1 Department of Cardiovascular Anesthesia and Intensive Care, Vita-Salute University, IRCCS San Raffaele Hospital, Milan, Italy
2 Department of Mathematics University of Milan, Milan, Italy


Aim. A high postoperative peak of cardiac Troponin I is associated to an increased risk of morbidity and mortality after cardiac operations. The aim of this study was to investigate the release of cardiac Troponin I in different cardiac surgical procedures.
Methods. This was a prospective, single-centre study performed at the IRCCS San Raffaele Hospital in Milan, Italy. The study group consisted of 194 consecutive patients undergoing cardiac surgery. For each of them creatinkinase MB and cardiac Troponin I were assayed preoperatively, at ICU arrival, 4 h and 18 h postoperatively.
Results. Different cardiac surgical procedures were characterized by different release of cardiac biomarkers (P<0.001, ANOVA test). Off-pump coronary artery bypass grafting (CABG) was associated to the smallest amount of myocardial injury while mitral valve replacement produced the largest amount of biomarkers release. Patients who suffered a postoperative cardiac event released more myocardial necrosis biomarkers than those with an uneventful course (P=0.01).
Conclusion. We showed that each type of cardiac operation has a peculiar amount of myocardial necrosis biomarkers: mitral valve replacement in particular is associated to the highest release of cardiac biomarkers.

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