Total amount: € 0,00
Online ISSN 1827-1596
SMART 2006 - Milan, May 10-12, 2006
Lamia B., Monnet X., Teboul J. L.
Unit of Medical Intensive Care Bicetre University Hospital University Paris XI, Paris, France
The arterovenous difference in carbon dioxide tension (∆PCO2) can be calculated after simultaneous sampling of arterial blood (PaCO2) and of mixed venous blood from the distal of a pulmonary artery catheter (PvCO2). Under physiological conditions, ∆PCO2 ranges from 2 to 5 mmHg. The ∆PCO2 depends on carbon dioxide and cardiac output by a complex fashion. In this article, we detail the influence of these factors on ∆PCO2 in normoxic conditions and in hypoxic conditions. We bring evidence that ∆PCO2 cannot serve as a marker of tissue hypoxia contrary to what was initially thought. However, ∆PCO2 can be considered as a marker of the adequacy of venous blood flow (i.e. cardiac output) to remove the total CO2 produced by the peripheral tissues. In this regard, the knowledge of ∆PCO2 should help the clinicians for the decision of giving therapy aimed at increasing cardiac output.