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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596


Minerva Anestesiologica 2006 May;72(5):309-19



Remifentanil vs fentanyl with a target controlled propofol infusion in patients undergoing craniotomy for supratentorial lesions

Del Gaudio A. 1, Ciritella P. 1, Perrotta F. 2, Puopolo M. 2, Lauta E. 3, Mastronardi P. 4, De Vivo P. 1

1 Department of Anaesthesia and Intensive Care IRCCS H ''Casa Sollievo della Sofferenza'' S. Giovanni Rotondo, Foggia, Italy
2 Department of Organ and System Pathophysiology Istituto Superiore di Sanità, Rome, Italy
3 Department of Anaesthesia and Intensive Care University of Bari, Bari, Italy
4 Department of Anaesthesia and Intensive Care University of Naples, Naples, Italy

Aim. Remifentanil hydrochloride is an ultra-short acting µ-opioid receptor agonist. This study compared the use of remifentanil with that of fentanyl during elective supratentorial craniotomy in a target controlled infusion (TCI)-propofol anesthesia regimen and evaluated the quality of recovery from anesthesia.
Methods. After written informed consent for this prospective study, 40 adult patients were randomly divided into 2 groups: in group F analgesia was provided with fentanyl 2-3 µg kg-1 h-1 and in group R with remifentanil 0.25 µg kg-1 h-1. Aaesthesia was induced with thiopental and pancuronium bromide, and maintained with propofol-TCI, pancuronium, air and oxygen and fentanyl (group F) or remifentanil (group R), respectively. After tracheal intubation, infusion rate of remifentanil was reduced and then adjusted to maintain stable hemodynamics. Hemodynamics and recovery time were monitored for 60 min after surgery. Analgesic requirements, propofol intraoperative consumption, nausea and vomiting in postoperative period were monitored. Recovery was evaluated according to a modified Aldrete score.
Results. Baseline hemodynamics were similar in both groups. Mean arterial pressure differed between the 2 groups (P<0.05) with the greatest decrease in group R during dura opening (P<0.001). Postoperative mean arterial pressure was higher in group R. Patients in group R exhibited a faster recovery. The incidence of nausea and vomiting was similar in the 2 groups. Noteworthy, there was a reduction in the amount of propofol used in group R.
Conclusion. Remifentanil appears to be a reasonable alternative to fentanyl during elective surgery of supratentorial lesions.

language: English, Italian


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