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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2005 October;71(10):601-7

language: English, Italian

Blunted inflammatory response to lipopolysaccharide endotracheal instillation due to thermal preconditioning

Di Filippo A. 1, Rinaldi S. 1, Pascente C. 1, Messeri D. 2, De Gaudio A. R. 1

1 Section of Anaesthesia Department of Critical Care University of Florence, Florence, Italy
2 Unit of Infectious Disease ASL-3 Pistoia, Pistoia, Italy


Aim. Heat shock proteins (HSPs), induced by thermal stress, make the cells more resistant to following stress. We aimed to verify if rats heating reduces the production of TNF-α in a model of acute respiratory distress syndrome (ARDS).
Methods. We divided 34 Wistar rats in Group A and Group B. The rats of Group A received thermal shock and tracheal instillation of lipopolysaccharide (LPS), the rats of Group B only tracheal instillation of LPS. All the rats have been then subdivided in 6 subgroups sacrificed at different times after instillation of LPS: A30 and B30 at 30 min, A90 and B90 at 90 min and A180 and B180 at 180 min. We dosed the serum concentration of TNF-α and the values of every subgroup have been compared with the Student t-test.
Results. The serum concentration of TNF-α in the subgroup A90 resulted significantly lower than in the subgroup B90.
Conclusion. The exposure to thermal stress resulting in the production of HSPs reduced the concentration of TNF-α in this model of ARDS.

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