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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
SMART 2005 - Milan, May 11-13, 2005
Minerva Anestesiologica 2005 June;71(6):357-60
Local anesthetics in pediatric anesthesia: an update
Department of Anesthesiology Critical Care and Surgery Pontchaillou Hospital, University of Rennes 1 Rennes, France
For several decades, bupivacaine has enjoyed great clinical popularity as the first choice local anesthetic in pediatrics. However, introduction of ropivacaine and levobupivacaine, the two newer and presumably safer (thought to be less cardio- and neurotoxic than bupivacaine) local anesthetics, has challenged the position of bupivacaine as a gold standard for prolonged duration of analgesia. This review article summarized the metabolism, the criteria of choice and the safety use of new agents.