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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2004 November;70(11):753-61

language: English, Italian

Low dose remifentanyl infusion for analgesia and sedation in ventilated newborns

Stoppa F. 1, Perrotta D. 1, Tomasello C. 1, Cecchetti C. 1, Marano M. 1, Pasotti E. 1, Barbieri M. A. 2, Conti G. 3, Pirozzi N. 1

1 Intensive Care Unit, Emergency Department Bambino Gesù Pediatric Hospital (IRCCS) Rome, Italy
2 Pediatric Unit, Emergency Department Bambino Gesù Pediatric Hospital (IRCCS) Rome, Italy
3 Department of Anaestesiology and Critical Care Catholic University of the Sacred Heart Rome, Italy


Aim. The aim of this study was to evaluate the analgesic effects of remifentanyl® on mechanically ventilated newborns.
Methods. Eighteen newborns, mechanically ventilated, were submitted to continuous infusion of R. A pain scale was used to evaluate comfort during mechanical ventilation. Data were collected at T0, T1, Tn, T ext, T post-ext; statistical analysis was performed by Student’s t test and Pearson coefficient.
Results. Mean R infusion time was 66.94±22.24 h, with mean dose of R 0.146±0.038 γ/kg/min. Mean time to reach comfort was 20±13.11 h with a mean infusion of R equal to 0.173±0.146 γ/kg/min; R was 0.18±0.039 γ/kg/min on pressure controlled ventilation and R was 0.09± 0.045 γ/kg/min on assisted ventilation. Statisti-cally significant was considered the decrease in HR as well as the increase of SpO2 at T0 vs 30 min after infusion.
Conclusion. No adverse effects were observed during and after infusion.

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