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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
INTENSIVE CARE SMART 2004 - Milan, May 12-14, 2004
Minerva Anestesiologica 2004 April;70(4):189-91
Hemofiltration in the prevention of radiocontrast agent induced nephropathy
Marenzi G., Bartorelli A. L.
Monzino Heart Center, IRCCS, Institute of Cardiology, University of Milan, Milan, Italy
Aim. The aim of the study was to investigate the role of hemofiltration in preventing contrast nephropathy in patients with renal failure.
Methods. We randomized 114 renal failure patients undergoing percutaneous coronary interventions (PCI) to either peri-procedural hemofiltration or saline hydration.
Results. Contrast nephropathy occurred in 5% of hemofiltration-treated patients and in 50% in controls (P<0.01). In-hospital event rate as well as in-hospital and 1-year mortality rates were lower in patients treated with hemofiltration.
Conclusion. In patients with renal failure undergoing PCI, peri-procedural hemofiltration is effective for the prevention of contrast nephropathy, and is associated with improved in-hospital and long-term outcome.