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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596


Minerva Anestesiologica 2003 May;69(5):376-80

SMART 2003 - Milan, may 28-30, 2003 


Antithrombin III in burned children

Del Principe D.

Clinica Pediatrica, Università di Roma Tor Vergata, Roma, Italia

We studied haemostatic parameter and Antithrombin III (ATIII) level in 50 consecutive admissions for severe burns between 1990 to1994 to the Centro Grandi Ustionati Ospedale S. Eugenio, Rome. The criteria for inclusion in the study were age <16 years and the presence of major burns (extent of the burns >30 and second and third degree burns). Treatment consisted of initial fluid resuscitation and early excision and grafting of burn wounds and critical care support by a multidisciplinary team. Burn-related variables haemostatic values and the conditions of microcirculation were proposed and analysed with the help of Fisher exact test, χ2 test, logistic regression and discriminant analysis.
By the discriminant analysis, the coefficients of the standardized functions and the percentage of correctly classified individuals were calculated. The analysis showed total burned surface turned out to be the best predictor of survival. High discrimination efficiency was observed for age, weight, burn type (flame, scald contact chemical electrical).
By the logistic regression, the total burned surface confirmed to be the best predictor of survival and between the haemostatic variables ATIII give a significant value (p=0.0244).
Moreover, it is noteworthy that ATIII level at the onset of the disease gives a significant correlation with mortality (p=0.0005). The Fisher test showed a significant association between ATIII level and death (p=0.0005). This was confirmed by the χ2 test (p=0.00027). Considering the AT deficiency in patients with thermal injuries, we conducted a pilot study to assess AT concentrate infusions for safety and efficacy in thermal injury. The patients received AT concentrate infusions every 8 hours to raise the plasma level to 100 % in the first 72 hours after injury and were compared with control pa­tients with burns. Day4 levels were 105%±20% in patients treated with AT patients versus 50%±14% in the control patients (P < 0.001). In the group treated with AT the time to microcirculation recovery was shorter (P < 0.02).

language: Italian


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