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Online ISSN 1827-1596
Fink M. P.
From the University of Pittsburgh Medical School Watson Professor of Surgery Chief, Division of Critical Care Medicine Anesthesiology and Critical Care Medicine
It is increasingly apparent that organ dysfun-ction in sepsis is caused, at least in part, by an acquired intrinsic derangement in cellular oxidative adenosine triphosphate (ATP) production. We have termed this phenomenon “cytopathic hypoxia”. Although several different but mutually compatible mechanisms might account for the development of cytopathic hypoxia in sepsis, recent data from our laboratory point to activation of the nuclear enzyme, poly-ADP-ribosyl polymerase (PARP), as being the most important.