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MINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2001 April;67(4):290-1

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Cytopathic hypoxia in sepsis: a true problem?

Fink M. P.

From the University of Pittsburgh Medical School Watson Professor of Surgery Chief, Division of Critical Care Medicine Anesthesiology and Critical Care Medicine Pittsburgh, USA


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It is increas­ing­ly appar­ent ­that ­organ dys­fun-cti­on in sep­sis is ­caused, at ­least in ­part, by an ­acquired intrin­sic derange­ment in cel­lu­lar oxi­da­tive aden­o­sine tri­phos­phate (ATP) pro­duc­tion. We ­have ­termed ­this phe­nom­e­non “cyto­path­ic hypox­ia”. ­Although sev­er­al dif­fer­ent but mutu­al­ly com­pat­ible mech­a­nisms ­might ­account for the devel­op­ment of cyto­path­ic hypox­ia in sep­sis, ­recent ­data ­from our labor­a­to­ry ­point to acti­va­tion of the nucle­ar ­enzyme, ­poly-ADP-ribo­syl poly­me­rase (­PARP), as ­being the ­most impor­tant.

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