Advanced Search

Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 2000 November;66(11) > Minerva Anestesiologica 2000 November;66(11):799-806



A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596


Minerva Anestesiologica 2000 November;66(11):799-806



Anesthetic observations in Cornelia de Lange syndrome

Moschini V., Ambrosini M. T., Sofi G.

Azienda Ospedaliera Istituti Clinici di Perfezionamento - Milano Servizio di Anestesia e Rianimazione

Background. Retrospective ­study in pedi­at­ric ­patients ­with Cornelia de Lange syn­drome under­go­ing dif­fer­ent sur­gi­cal oper­a­tions, in ­order to crit­i­cal­ly eval­u­ate the anes­the­sio­log­ic ­aspects of ­this syn­drome.
Methods. Between January 1997 and December 1998, 42 ­patients under­go­ing diag­nos­tic exam­ina­tions (eso­phag­o­gas­tros­co­py, ocu­lis­tic vis­it) or sur­gery (­total exo­don­tia, fun­dop­li­ca­tio for esoph­a­geal ­reflux, cor­rec­tion of labi­o­pal­a­tos­chi­sis) ­have ­been stud­ied. The anaesthes­io­log­ic tech­nique has ­been sim­i­lar for all the cas­es.
Results. Any par­tic­u­lar dif­fi­cul­ty or incon­ven­ience in com­par­i­son ­with ­patients ­with the ­same ­range of age, or par­tic­u­lar intra­op­er­a­tive dif­fi­cul­ties ­have ­been ­observed. In ­only one ­patient the McCoy laryn­go­scope was ­used due to dif­fi­cult intu­ba­tion (Cormack and Lehane III).
Conclusions. Short ­neck, ­ogive pala­tum, ­cleft pal­ate, microg­na­tia, uro­gen­i­tal and gas­troen­ter­ic anom­a­lies, esoph­a­geal ­reflux, togeth­er ­with ­heart ­defects (15% of cas­es), can com­pli­cate the ­peri and post­op­er­a­tive peri­od in ­these ­patients. A care­ful pre­op­er­a­tive eval­u­a­tion and a care­ful per­i­op­er­a­tive man­age­ment, may ­decrease anes­thet­ic com­pli­ca­tions in Cornelia de Lange syn­drome to the ­same ­range of nor­mal ­patients.

language: Italian


top of page