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Online ISSN 1827-1596
Di Massa A., Scardigli M. *, Bruni L. *, Valentino L. *
From the Università degli Studi - Siena Dipartimento di Scienze Odontostomatologiche Cattedra di Terapia del Dolore
*Istituto di Anestesiologia e Rianimazione
Ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) largely used in adults, deserves particular attention for postoperative pain therapy in children, even if it is not officially approved for paediatric use. We have examined a lot of studies about the use of ketorolac for paediatric postoperative pain, pointing out pharmacological and pharmacokinetic properties and side effects. There are significant differences in pharmacokinetic parameters, doses, routes of administration, length of treatment, side effects, usage precautions and pharmacological interactions between children and adults. Amongst the many drugs available, ketorolac seems to be particularly efficient for postoperative pain therapy in children too.