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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
Minerva Anestesiologica 2000 July-August;66(7-8):561-4
Non invasive ventilation in the treatment of FUdr-induced lesional pulmonary oedema
Conti G. *, Spadetta G., Rocco M., Antonelli M., Ru-scio L., Gionfrida E., Angiuli G.
From the Università degli Studi Roma «La Sapienza»
*Università Cattolica del Sacro Cuore - Roma Istituto di Anestesiologia e Rianimazione
2-deoxy-5- fluoruridine, also known as floxuridine (FUdr) is a fluoropyridine antimetabolite, used in the treatment of metastatic renal cell carcinoma. We report the first case of lesional pulmonary oedema developed after receiving Fudr, recently treated in our unit. The patient refused endotracheal intubation, and was successfully treated associating non-invasive ventilation (NIV) with full-face mask to steroid treatment. The authors conclude that mechanical ventilation via face-mask can be an effective, comfortable, dignified method of support for patients with end-stage disease and acute respiratory failure.