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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
Minerva Anestesiologica 2000 July-August;66(7-8):555-9
Retinoic acid syndrome. Severe respiratory insufficiency treated with CPAP
Tommasino C., De Felice L., Colombo S., Salaris D., Capocasa T., Giudici D.
Università degli Studi - Milano IRCCS H San Raffaele Cattedra di Anestesiologia e Rianimazione (Direttore: Prof. G. Torri)
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Retinoic acid syndrome is a potentially life-threatening complication of therapy for acute promyelocytic leukemia (APL) with all-transretinoic acid (ATRA). The case of a 55-year old male patient admitted to the hospital because of a bleeding diathesis is reported. APL was diagnosed and he underwent tratment with idarubicin and ATRA (GIMEMA protocol); 24 hrs after ATRA treatment he developed retinoic acid syndrome and was admitted to the Intensive Care Unit because of severe respiratory insufficiency (dyspnoea, tachypnea and severe hypoxemia (SpO2 75%). Pulmonary insufficiency was treated non-invasively with CPAP and the patient recovered from pulmonary distress one week later.