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CURRENT ISSUEMINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Anestesiologica 2000 May;66(5):362-6

 NUTRITIONAL STATUS AND IMMUNOLOGICAL COMPETENCE

Rational base and clinical results of immunonutrition

Gentilini O., Braga M., Gianotti L.

From the Department of Surgery IRCCS S. Raffaele Hospital, Milano

The use of enter­al for­mu­las sup­ple­ment­ed ­with immu­non­u­trients has ­been dem­on­strat­ed to mod­ulate gut func­tion, inflam­ma­to­ry and ­immune ­response ­after trau­ma in ­both experi­men­tal and clin­i­cal set­tings. Most stud­ies ­have ­focused on glu­ta­mine, argi­nine, w-3 fat­ty ­acids and nucle­o­tides. Glutamine is an impor­tant ­source of nitro­gen and cal­o­ries and ­might be par­tic­u­lar­ly use­ful in deplet­ed ­patients or in ­patients affect­ed by ­small bow­el syn­drome. Its use in the crit­i­cal ­patient ­remains con­tro­ver­sial. Data col­lect­ed in two dif­fer­ent ­recent ­meta-anal­y­sis con­sis­tent­ly con­firmed ­that enter­al for­mu­las ­enriched ­with, argi­nine, w-3 fat­ty ­acids and nucle­o­tides ­reduced infec­tious com­pli­ca­tions and hos­pi­tal ­stay ­after ­planned sur­gery, and ­decreased infec­tious com­pli­ca­tions, hos­pi­tal ­stay and ven­ti­la­tor ­days in the crit­i­cal­ly ill. Mortality ­seems not to be affect­ed by enter­al admin­is­tra­tion of immu­non­u­trients.

language: English


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