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MINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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ORGAN DAMAGE AND SEPSIS  


Minerva Anestesiologica 2000 May;66(5):337-42

language: English

Cytopathic hypoxia. A concept to explain organ dysfunction in sepsis

Fink M. P.

From the Critical Care Medicine, Division University of Pittsburgh Medical School


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The ­most com­mon ­cause of ­death in ­patients ­with sep­sis is the mul­ti­ple ­organ dys­func­tion syn­drome (­MODS). One impor­tant fac­tor under­ly­ing the path­o­gen­e­sis of ­MODS may be sep­sis-­induced alter­a­tions in cel­lu­lar ener­gy metab­olism due to ­acquired intrin­sic derange­ments in cel­lu­lar res­pi­ra­tion, a phe­nom­e­non ­that ­might be ­called “cyto­path­ic hypox­ia”. A num­ber of dif­fer­ent bio­chem­i­cal mech­a­nisms ­have ­been pos­tu­lat­ed to ­account for cyto­path­ic hypox­ia in sep­sis, includ­ing rever­sible inhi­bi­tion of cyto­chrome oxi­dase by ­nitric ­oxide, irre­ver­sible inhi­bi­tion of one or ­more mit­o­chon­dri­al res­pir­a­to­ry com­plex­es by per­oxy­ni­trite, and acti­va­tion of the nucle­ar ­enzyme, ­poly-(ADP-ribo­syl)-poly­me­rase.

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