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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
MECHANICAL VENTILATION IN ANAESTHESIA
Minerva Anestesiologica 2000 May;66(5):307-313
Nitric oxide: modulation of the pulmonary circulation
Bigatello L. M.
From the Department of Anesthesia and Critical Care Massachussets General Hospital Harvard Medical School, Boston, Massachusetts, USA
Nitric oxide (NO) is synthetized throuhout the body by the enzyme NO synthase (NOS), cyclic GMP transduction pathway causes pulmonary vasodilatation anti-platelets aggregation and inhibition of leukocyte adhesion. Inducible NOS is expressed in leukocytes in response to a variety of inflammatory stimuli and can be inhibited by corticosteroids. Inhaled NO is a selective pulmonary vasodilator. In USA inhaled NO was approved by FDA for hypoxemic respiratory failure in infants and children. In adults it may be useful in various clinical therapy: pulmonary hypertension, lung transplantation, ARDS but new clinical investigations are necessary.