Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 2000 May;66(5) > Minerva Anestesiologica 2000 May;66(5):307-313

CURRENT ISSUEMINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

 

MECHANICAL VENTILATION IN ANAESTHESIA  


Minerva Anestesiologica 2000 May;66(5):307-313

language: English

Nitric oxide: modulation of the pulmonary circulation

Bigatello L. M.

From the Department of Anesthesia and Critical Care Massachussets General Hospital Harvard Medical School, Boston, Massachusetts, USA


FULL TEXT  REPRINTS


Nitric oxide (NO) is synthetized throuhout the body by the enzyme NO synthase (NOS), cyclic GMP transduction pathway causes pulmonary vasodilatation anti-platelets aggregation and inhibition of leukocyte adhesion. Inducible NOS is expressed in leukocytes in response to a variety of inflammatory stimuli and can be inhibited by corticosteroids. Inhaled NO is a selective pulmonary vasodilator. In USA inhaled NO was approved by FDA for hypoxemic respiratory failure in infants and children. In adults it may be useful in various clinical therapy: pulmonary hypertension, lung transplantation, ARDS but new clinical investigations are necessary.

top of page