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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2000 January-February;66(1-2):25-32

language: Italian

Emergence and postoperative course after sevoflurane anaesthesia versus propofol anaesthesia

Falsini S. *, Girardi G. *, Melani A. M. *, Novelli G. P. *

*Istituto di Anestesia e Rianimazione dell’Università degli Studi di Firenze (Direttore: Prof. G.P. Novelli)


Background. To compare the postoperative period, with particular regard to occurrence of adverse effects at the time of emergence from anaesthesia, recovery parameters, any post-surgical analgesia requirements and laboratory tests changes in 80 ASA I and II patients undergoing sevoflurane or propofol anaesthesia for elective extracavity surgery. Design: a prospective randomized clinical trial.
Methods. Patients were randomly allocated into two groups: in the first group, thiopentone was administered for induction of anaesthesia and sevoflurane for maintenance; the second group received propofol either for induction of anaesthesia and maintenance. All patients received vecuronium for neuromuscular blockade and fentanyl as needed. At the end of surgery, the occurrence of adverse effects, recovery parameters, time of discharge from recovery area, any post-surgical analgesia requirements, time of walking resumption and any laboratory tests changes were recorded.
Results. In the sevoflurane group times of discharges from recovery area were significantly faster. In both groups total bilirubin increase was recorded until 72 hours after the end of anaesthesia.
Conclusions. Significant differences of post-operative adverse effects and laboratory tests changes were not recorded in both groups of anaesthetics.

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