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CURRENT ISSUEMINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,036

Frequency: Monthly

ISSN 0375-9393

Online ISSN 1827-1596

 

Minerva Anestesiologica 1999 September;65(9):637-9

CRITICAL AND INTENSIVE THERAPY 

    ORIGINAL ARTICLES

Evaluation of the util­ity of ser­o­log­i­cal ­tests in the diag­no­sis of can­di­de­mia

Pallavicini F. 1, Izzi I. 1, Pennisi M. A. 2, Morace G. 3, Portaccio G. G. 1, Bello G. 2, Iodice F. 2, Godino D. 2, Del Borgo C. 1, Proietti R. 2

1 Istituto di Clinica ­delle Malattie Infettive, Università Cattolica del Sacro Cuore - Roma;
2 Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore - Roma;
3 Istituto di Microbiologia, Università Cattolica del Sacro Cuore - Roma

Background. It has ­been ­observed ­that the inci­dence and prev­a­lence of can­di­da infec­tions in crit­i­cal­ly ill non-immu­no­com­prom­ised ­patients has ­increased. This ­study ­aims to eval­u­ate the util­ity of the use of ser­o­log­i­cal ­tests (dou­ble immu­no­dif­fu­sion and Cand -Tec Test) for the deter­mi­na­tion of can­di­de­mia.
Methods. A ret­ro­spec­tive eval­u­a­tion­ is ­made of 214 ­patients admit­ted to the Intensive Care Unit (ICU) of the Agostino Gemelli University Polyclinic dur­ing a peri­od of 42 ­months. The dou­ble immu­no­dif­fu­sion tech­nique was uti­lized for the deter­mi­na­tion of Candida anti­bod­ies. The Cand-Tec ­latex agglu­ti­na­tion ­test was per­formed to eval­u­ate the pres­ence of Candida anti­gen. Four hun­dred and fif­ty-­five anti­gen and anti­body ­tests ­were per­formed.
Results. Thirty-six ­patients (16.8%) devel­oped an inva­sive can­di­di­a­sis. The sen­si­tiv­ity and spec­i­fic­ity of anti­body detec­tion ­test was 29 and 67 respec­tive­ly; the pos­i­tive pre­dic­tive val­ue was 15 and the neg­a­tive pre­dic­tive val­ue was 82. The sen­si­tiv­ity and spec­i­fic­ity of the anti­gen detec­tion ­test ­ranged ­between 82 and 3 and ­between 8 and 98 respec­tive­ly accord­ing to dif­fer­ent cut-off ­titre; the pos­i­tive pre­dic­tive val­ue was low (13-17%) and the neg­a­tive pre­dic­tive val­ue ­decreased ­from 70 to 29.
Conclusions. The util­ity of the use of ser­o­log­i­cal ­tests in the diag­no­sis of can­di­de­mia is extreme­ly lim­it­ed. The ­gold stan­dard for the deter­mi­na­tion of Candida sep­sis ­remains the dem­on­stra­tion of can­di­da in ­blood or in tis­sues.

language: English


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