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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
ORIGINAL ARTICLES CRITICAL AND INTENSIVE THERAPY
Minerva Anestesiologica 1999 July-August;65(7-8):515-20
Gastroprotective effect of propacetamol against cold/restraint stress ulcers in rats
Marazova K. 1, Klouchek E. 1, Popov A. 1, Frangov P. 2, Di Massa A. 3
1 Department of Pharmacology, Faculty of Medicine;
2 Department of Anaesthesiology and Intensive Treatment, Faculty Hospital “S. Anna”, Sofia (Bulgaria);
3 Department of Stomatological Sciences, University of Siena, Siena
Background. Comparative evaluation of propacetamol and morphine on the cold restraint stress ulcers in rats.
Methods. The present study compared the effects of propacetamol hydrochloride (250 and 500 mg.kg-1 i.p.) and morphine hydrochloride (10 mg.kg-1 i.p.) against gastric mucosal damage induced by cold/restraint stress (4°C for 3 h) in rats. Morphometrical and histomorphological studies were carried out. Mean ulcer number and length were calculated.
Results. The results show that propacetamol in the lower dose tested decreases the ulcer number and length by 56.4% (p>0.05) and by 68.94% (p<0.01). After propacetamol 500 mg.kg-1 the ulcer number and length were found significantly decreased by 74.83% and 83.5%. Marked decrease was found in morphine-pretreared group (-77.03% and -85.09%). The morphometrical results have been confirmed histomorphologically.
Conclusions. It might be concluded that morphine (10 mg.kg-1) and propacetamol (500 mg.kg-1) are equipotent in their ability to prevent the stress ulceration in rats.