Home > Journals > Minerva Anestesiologica > Past Issues > Minerva Anestesiologica 1998 July-August;64(7-8) > Minerva Anestesiologica 1998 July-August;64(7-8):345-50

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA ANESTESIOLOGICA

A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,623


eTOC

 

ORIGINAL ARTICLES  CRITICAL AND INTENSIVE THERAPYFREEfree


Minerva Anestesiologica 1998 July-August;64(7-8):345-50

Copyright © 1998 EDIZIONI MINERVA MEDICA

language: English

Rapid turnover proteins in critically ill ICU patients. Negative acute phase proteins or nutritional indicators?

Casati A., Muttini S., Leggieri C., Colombo S., Giorgi E., Torri G.

University of Milan, IRCCS H San Raffaele, Milan, Department of Anaesthesiology and Intensive Care


FULL TEXT  


Back­ground. ­Rapid turn­over pro­teins are ­often ­used as meta­bolic indi­ca­tors in ­patients ­receiving nutri­tional ­therapy. How­ever, ­their plas­matic con­cen­tra­tion can be influ­enced by acti­va­tion of ­acute ­phase reac­tion due to ­stress. The aim of ­this pros­pec­tive, obser­va­tional ­study was to eval­uate ­changes of pos­i­tive and neg­a­tive ­acute ­phase pro­teins in mechan­i­cally ven­ti­lated ICU ­patients ­with ­acute ­stress.
­Methods. Plas­matic con­cen­tra­tions of pre­al­bumin (PRA), ­retinol-­binding pro­tein (RBP), c-reac­tive pro­tein (CRP) as ­well as ­resting ­energy expen­di­ture (REE) and ­nitrogen bal­ance ­were meas­ured in ­thirty ICU ­patients ­before ­starting nutri­tional sup­port (Base­line) and ­then ­after 3 and 8 ­days of paren­teral nutri­tion (TPN).
­Results. Plas­matic con­cen­tra­tions of CRP ­were ­high at base­line and did not ­change (p=0.47), ­while RBP and PRA ­were low and pro­gres­sively ­increased ­during the ­study (p=0.0001 and p=0.004). Per­centage ­changes ­from base­line of ­both PRA and RBP ­were sig­nif­i­cantly cor­re­lated ­with ­nitrogen bal­ance (p=0.01 and p=0.009); ­while no sig­nif­i­cant cor­re­la­tion was ­observed ­between ­changes of ­rapid turn­over pro­teins and CRP (p=0.72 and p=0.10).
Con­clu­sions. All the var­i­ables ­involved in the ­study are ­known to be influ­enced by ­both meta­bolic ­state and res­o­lu­tion of inflam­ma­tion. How­ever, the ­observed ­changes of ­rapid turn­over pro­teins sig­nif­i­cantly cor­re­late ­with ­nitrogen bal­ance in the ­face of a per­sis­tent inflam­ma­tion, as doc­u­mented by CRP plas­matic con­cen­tra­tions. ­This sug­gests ­that RBP and PRA mon­i­toring may be ­used as com­ple­ment clin­ical eval­u­a­tion of nutri­tional ­therapy ­also in ICU ­patients ­with ­ongoing inflam­ma­tion.

top of page

Publication History

Cite this article as

Corresponding author e-mail