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A Journal on Anesthesiology, Resuscitation, Analgesia and Intensive Care
MONITORING, NEURORIANIMATION, SYSTEMIC HOMEOSTASIS, VASOSPASM TREATMENTS PROCEEDINGS OF THE VIDEOCONFERENCE - October 5, 1996
SUBARACHNOID HEMORRHAGE: A MULTIDISCIPLINARY APPROACH - II
Minerva Anestesiologica 1998 May;64(5):217-20
Prevention and treatment of vasospasm in SAH-patients
Tomasello F., D'Avella D.
Università degli Studi - Messina, Clinica Neurochirurgica
The overall data concerning the incidence of angiographyc and clinical vasospasm are reported. Furtheremore, the pathogenetic mechanisms of vasospasm with regard to vasotoxic agents, vasogenic agents and CSF blockage are discussed together with the mechanisms affecting platelet aggregation, decrease of prostacyclins, and increase of endothelin. At present, therapeutic golden standard, i.e. (triple H therapy), calcium-antagonist, fibrinolitics and antioxidizing agents are debated concerning their clinical applications, first, during and after any possible surgical or endovascular treatment of the source of bleeding, i.e., the aneurysm.