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Online ISSN 1827-1596
CRITICAL AND INTENSIVE THERAPY
Fiore G., Donadio P. P., Gianferrari P., Santacroce C., Guermani A.
Azienda Ospedaliera San Giovanni Battista, Sede Molinette - Torino, III Anestesia e Rianimazione Ospedaliera
Objective. To evaluate CVVH (Continuous Veno-Venous Hemofiltration) as acute renal replacement treatment in postoperative care of liver transplantation.
Design. Retrospective study.
Setting. Intensive Care Unit, year 1995.
Patients. 86 OLT performed in 1995, 11 of them underwent acute renal replacement treatment. In the same period, in the ICU were admitted 237 patients, and 20 underwent acute renal replacement treatment (control group).
Evaluation with SOFA (Sepsis-related Organ Failure Assessment) score.
Intervention. CVVH performed heparin free, pump system, polyamide or polysulphone 0.6 mq membrane hemofilter device, blood flow 150-200 ml/min, UF rate 1000-1200 ml/h, clearance 16-20 ml/min.
Measurements. Coagulation monitoring (PT as INR, PTT, fibrinogen, antithrombin III, d-dimer, platelet count) was performed 3 times a day or on variation of the clinical conditions.
Results. SOFA score did not differ between the two groups. Mortality was higher in the patients treated with CVVH. CVVH was performed from 16 to 18 hrs/day for 9.90±2.33 days. Three patients developed clinical bleeding before CVVH, 3 during CVVH but 1 of them underwent repeated surgical procedures.
Conclusions. We cannot demonstrate that CVVH doesn’t affect bleeding, but we can say that, for the complexity of the post OLT patients, CVVH can be the treatment of choice in case of renal replacement treatment.