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MEDICINA DELLO SPORT

A Journal on Sports Medicine


Official Journal of the Italian Sports Medicine Federation
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Medicina dello Sport 2014 June;67(2):251-9

language: English, Italian

Influence of L-carnitine supplementation on exercise-induced muscle damage

Nakhostin-Roohi B. 1, Khoshkhahesh F. 2, Parandak K. 3, Ramazanzadeh R. 1

1 Department of Exercise Physiology, Ardabil Branch, Islamic Azad University, Ardabil, Iran;
2 University of Mohaghegh-Ardabili, Ardabil, Iran;
3 Rasht Branch, Islamic Azad University, Ardabil, Iran


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AIM: This study was conducted to assess the effect of a two-week L-carnitine supplementation on exercise-induced muscle damage, as well as antioxidant capacity after a bout of strenuous exercise in active healthy young men.
METHODS: Twenty active healthy men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: L-carnitine (C group; N.=10) and placebo group (P group; N.=10). The participants took supplementation (2000 mg L-carnitine) or placebo (2000 mg lactose) daily for 14 days before main trial. Afterwards, participants ran 14 km. Blood samples were taken before supplementation, before exercise, immediately, 2 h and 24 h after exercise. Total antioxidant capacity (TAC), creatine kinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured.
RESULTS: Plasma TAC increased significantly 14 days after supplementation and 24 h after exercise in C group compared with P group (P<0.05). Serum CK, LDH, ALT, and AST significantly increased after exercise in both groups (P<0.05). Serum LDH and ALT were significantly lower in C group than P group 2 h and 24 h after exercise (P<0.05). Furthermore, CK, and AST were significantly lower in C group compared with P group just 24 h after exercise (P<0.05).
CONCLUSION: These results suggest two-week daily oral supplementation of L-carnitine has been able to promote antioxidant capacity before and after exercise and decrease muscle damage markers through possibly inhibition of exercise-induced oxidative stress.

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