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A Journal on Sports Medicine

Official Journal of the Italian Sports Medicine Federation
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Medicina dello Sport 2013 September;66(3):315-24

language: English, Italian

Effects of different resistance exercise intensity on mitochondrial DNA deletions in young athletes

Rahimi R. 1, Salehi Z. 2, Mousavi Beneh-Hoor Z. 2

1 Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran;
2 Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran


Aim: The purpose of the present study was to examine the effect of resistance exercise (RE) with different intensities on mitochondrial DNA deletions including 4977-bp (mtDNA4977 deletion), 8.7 kb, 7.5 kb and 7.4 kb deletion in young athletes.
Methods: Ten resistance-trained men (age: 21±2.30 year; weight: 74.71±8.73 kg; height: 175.14±5.95 cm) performed high intensity RE (4 sets of 5 exercises at 90% of 1RM with 3 min rest between sets) and moderate intensity RE (4 sets of 5 exercises at 75% of 1RM with 1 min rest between sets) on a separate occasion in a counterbalanced order. Blood samples were obtained before (Pre) and immediately after (Post) RE for analyzing mtDNA deletions in blood leucocytes by multiplex polymerase chain reaction (PCR).
Results: The results indicated that 8.7 kb, 7.5 kb, 7.4 kb and mtDNA4977 deletion, were not evident in leucocytes at Pre and Post during both RE intensities.
Conclusion: In conclusion, our findings showed that RE did not induce mtDNA deletions in resistance trained men, probably because of adaptations occurring owing to chronic resistance training.

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