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MEDICINA DELLO SPORT

A Journal on Sports Medicine


Official Journal of the Italian Sports Medicine Federation
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Medicina dello Sport 2011 March;64(1):21-30

language: English, Italian

Effects of aerobic and anaerobic training on inflammatory markers in rats

Mogharnasi M. 1, Gaeini A. A. 2, Sheikholeslami Vatani S. 3, Faraji H. 2

1 Department of Exercise Physiology, University of Sistan & Baluchestan, Zahedan, Iran
2 Department of Exercise Physiology, University of Tehran, Tehran, Iran
3 Department of Exercise Physiology, University of Kurdistan, Sanandaj, Iran
4 Department of Physical Education & Sport Science, Islamic Azad University Marivan Branch, Marivan, Iran


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The purpose of present study was to determine the effects of exercise type and a detraining phase on some inflammatory markers in rats. Twelve week old rats (N.=66) were divided into three groups: aerobic (55-85% VO2max, [N.=24]), anaerobic (100% VO2max or over, [N.=24]) and no training controls (N.=18). Exercise training was performed by treadmill running 3 day per week for 12 weeks. Six rats per aerobic and anaerobic group were maintained in detraining status from 8th week to end of the study. Serum samples were obtained after initial session, 8th week and 12th week for measurement of the IL-1β, TNF-α and sICAM-1. After initial session, IL-1β, TNF-α and sICAM-1did not changes. IL-1β, TNF-α and sICAM-1 decreased in aerobic group, whereas these factors were increased in anaerobic and control groups at the end of study. After detraining, IL-1β, TNF-α and sICAM-1 returned to the initial session levels. In conclusion, one bout of exercise does not alter markers of inflammation. Anaerobic training evokes significant increase in inflammatory markers, which may associated with progression of atherosclerotic diseases. In contrast, aerobic training plays a significant role in prevention of cardiovascular disease resulted in significant reduction of inflammatory markers. In addition, detraining period for 2 weeks was associated with loss of some adaptations after 8 weeks training period.

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