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A Journal on Sports Medicine

Official Journal of the Italian Sports Medicine Federation
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,163

Frequency: Quarterly

ISSN 0025-7826

Online ISSN 1827-1863


Medicina dello Sport 1998 March;51(1):41-6


Plasma cath­e­col­a­mines and nucle­o­tide-­related ­purine bases ­during moun­tain ­climbing

Pagano Dritto E. 1, Bianchi G. P. 2, Bargossi A. M. 1, Grossi G. 1, Moretti R. 3, Posabella G. 1, Marchesini G. 2

1 Lab­o­rat­orio Cen­tra­liz­zato, Pol­i­clinico ­Sant’Orsola, ­Bologna;
2 Dipar­ti­mento di Med­i­cina ­Interna, Car­di­oan­gio­logia, Epat­o­logia, Pol­i­clinico ­Sant’Orsola, ­Bologna;
3 Ser­vizio di Recu­pero e Rie­du­caz­ione Fun­zi­o­nale, Pol­i­clinico ­Sant’Orsola, ­Bologna

Climbing is a ­high-expen­di­ture ­sport, con­sisting of ­aerobic and anaer­obic exer­cise, per­formed at var­i­able ­strain, some­times for a ­long ­time. We ­aimed at ­defining the phys­io­log­ical ­changes to moun­tain ­climbing, ­related ­both to phys­ical ­strain and ­acute ­hypoxia, and the ­effects on ­human ­muscle ­energy bal­ance, by meas­uring cath­e­col­a­mine and oxy­pu­rine ­levels.
­Eight ­male ­well-­trained ­climbers, not accli­ma­tized to alti­tude, ­were ­studied ­during a moun­tain ­climbing ­between 2240 and 2500 m. ­Climbers ­were ­divided in ­pairs ­according ­their ­skill and ­ascended the 1st ­Torre del ­Sella ­through ­four dif­ferent ­routes. ­Blood sam­ples ­were ­drawn at def­i­nite ­times in the ­morning, ­before break­fast, on top of the moun­tain, and at the end of the exer­cise, ­after ­descent.
Basal nor­epi­neph­rine and epi­neph­rine ­were ­high-­normal and ­increased by 50-100% in ­response to exer­cise; dop­a­mine did not ­change. ­Also hypox­an­thine and xan­thine ­increased ­during exer­cise, and cor­re­la­tions ­were ­found ­between exer­cise-­induced nor­epi­neph­rine and hypox­an­thine. Lac­tate ­increased but did not ­reach the anaer­obic ­threshold ­value. ­Ammonia and ­uric ­acid ­were ­normal and did not ­change.
Changes in cath­e­col­a­mine and oxy­pu­rine ­levels ­appear to be ­more ­related to exer­cise-dura­tion ­more ­than ­strain inten­sity. ­Data sup­port a ­major ­role of rel­a­tive ­hypoxia.

language: English


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