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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2016 Feb 19

language: English

Serum nitrate and nitrite are associated with the prevalence of various chronic diseases except cancer

Nadezhda G. GUMANOVA 1, Alexander D. DEEV 1, Marina V. KLIMUSHINA 1, Alexander Y. KOTS 2, Svetlana A. SHALNOVA 1

1 National Research Center for Preventive Medicine of the Ministry of Healthcare, Moscow, Russia; 2 Department of Biochemistry and Molecular Medicine, The George Washington University, School of Medicine and Health Sciences, Washington, USA


BACKGROUND: Nitric oxide and its metabolites, nitrate and nitrite, are important regulators linked various diseases. We studied the association of fasting serum concentrations of nitrate and nitrite, combined as NOx, without special diet, with the prevalence of various chronic diseases.
METHODS: We have assayed fasting concentrations of NOx in a cohort of 1087 patients recruited to Stress Aging and Health in Russia study that represents male and female population in Moscow, Russia, over 55 years of age. Chronic diseases were recorded based on anamnesis and additional assays were run to characterize immune status and lipid and carbohydrate metabolism. Odds ratios were calculated to associate NOx concentrations with prevalence of chronic diseases in pooled deciles below or above borderline.
RESULTS: NOx over 44.7 µM were associated with increased prevalence of various chronic diseases such as diabetes type II, hyperthyroidism, coronary heart disease, gout and thrombosis/stroke. NOx 65.3 µM and above were associated with lowered prevalence of osteoporosis. NOx 74.6 µM and above were associated with significantly higher number of
patients who abstain from consumption of alcoholic beverages. NOx were not associated with cancer.
CONCLUSIONS: Thus, fasting concentrations of NOx in serum can be an important diagnostic parameter characteristic for specific chronic diseases.

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