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INTERNATIONAL ANGIOLOGY

A Journal on Angiology


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2017 August;36(4):295-8

DOI: 10.23736/S0392-9590.17.03820-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Interrelationship between venous and arterial thrombosis

Pavel POREDOŠ

Department of Vascular Diseases, Ljubljana University Medical Centre, Ljubljana, Slovenia


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In the past, arterial and venous thrombosis have been accepted as two completely different diseases. Recently, the thesis of two separate pathogenetic mechanisms of venous and arterial thrombosis has been challenged by accumulation of evidence which suggest that patients with atherothrombosis are at increased risk for venous thrombosis. Pathophysiological studies indicated that etiopathogenetic mechanisms of both diseases are similar and that coagulation and platelet activation participate in both venous and arterial thrombogenesis. Inflammation most probably represents the basic etiopathogenetic mechanism of arterial as well as venous thromboembolic disease, being a common mechanism through which different risk factors trigger thrombus formation in both veins and arteries. Atherothrombosis is accepted as a chronic inflammatory disease and the association between circulating inflammatory markers and venous thromboembolism also indicates an involvement of the inflammatory process in venous thrombosis. During inflammation, there is an increase in the production of procoagulant factors, a down-regulation of the anticoagulant mechanisms and an inhibition of the endogenic fibrinolytic activity. In line with the arguments which support the link between arterial and venous thrombosis is also the recognition that different risk factors are common in both diseases, such as age, metabolic syndrome, hypercholesterolemia and thrombophilia. A relation was also found between subjects with preclinical or clinical atherosclerotic disease and venous thromboembolism. These findings indicate close interrelationship between arterial atherothrombotic and venous thromboembolic disease. It could mean that atherosclerosis may induce venous thrombosis or that these two diseases have common risk factors which promote the development of both diseases.


KEY WORDS: Atherosclerosis - Thrombosis - Inflammation - Common risk factors - Coagulation

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Publication History

Issue published online: June 8, 2017
Article first published online: March 6, 2017
Manuscript accepted: February 27, 2017
Manuscript received: January 26, 2017

Cite this article as

Poredoš P. Interrelationship between venous and arterial thrombosis. Int Angiol 2017;36:295-8. DOI: 10.23736/S0392-9590.17.03820-2

Corresponding author e-mail

pavel.poredos@kclj.si