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A Journal on Angiology
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
International Angiology 2016 December;35(6):586-92
Ultrasound morphological changes in the carotid wall of Takayasu’s arteritis: monitor of disease progression
Wenting FAN 1, Jiaan ZHU 1, Jianguo LI 1, Wanlei ZHANG 1, Chun LI 2 ✉
1 Department of Ultrasound, Peking University People’s Hospital, Beijing, China; 2 Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China
BACKGROUND: The aims of this study were to examine ultrasound morphological changes in the carotid wall in cases of Takayasu’s arteritis and to thereby determine the value of ultrasound for assessments of Takayasu’s arteritis disease activity and follow-up studies.
METHODS: We used high-frequency ultrasound to analyze morphological changes in 51 Takayasu’s arteritis patients and compared the findings with clinical and laboratory parameters. A follow-up study of 20 patients was performed.
RESULTS: Five types of ultrasonographic images were observed in the carotid walls of Takayasu’s arteritis patients. Type III and type IV images were observed in younger patients; smaller wall thicknesses and less luminal stenosis were observed in these images. Type II and type IV images were more frequently obtained in cases involving active patients, whereas type I and type III images were more often acquired in cases involving inactive patients with significantly lower Indian Takayasu clinical activity scores. During follow-up, the wall thickness and outer diameter of the carotid increased in patients who relapsed and decreased in patients who remained in remission.
CONCLUSIONS: The five types of carotid ultrasound images reveal Takayasu’s arteritis-related morphological changes in the vessel wall, which reflect anatomical changes. Carotid ultrasound should play a central role in monitoring the progression of Takayasu’s arteritis.