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Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
Online ISSN 1827-1839
Naseer AHMAD 1, Neil THOMAS 2, Paramjit GILL 3, Francesco TORELLA 4
1 Manchester Vascular Centre, Manchester Royal Infirmary, Manchester, UK; 2 Department of Epidemiology, University of Birmingham, Birmingham, UK; 3 Department of Primary Care Research, University of Birmingham, Birmingham, UK; 4 Liverpool Vascular and Endovascular Service, Royal Liverpool University Hospital, Liverpool, UK
BACKGROUND: We aimed to determine whether revascularization modality affected risk of an above knee amputation (AKA) in patients with peripheral arterial disease.
METHODS: We used English hospital data and began by determining the number of major amputations and revascularization procedures performed between 1st April 2003- 31st March 2009. We then extracted demographic (age, sex, level of deprivation, treatment location), comorbidity (diabetes, hypertension, hypercholesterolemia, coronary heart disease, ischemic cerebrovascular disease and smoking) and revascularization modality (endovascular/surgical) data. Multi-variate analysis determined the odds ratios of an AKA in relation to previous revascularization attempts (if any).
RESULTS: Over the six year period, there were 25,312 major amputations of which 7544 (29.4%) were linked to a revascularization attempt. Level of amputation was significantly influenced by previous revascularization. Compared to patients not linked to revascularization, those requiring endovascular treatment were less likely to undergo an AKA (OR 0.82; 95% CI 0.75-0.90). Surgical (OR 1.16; 1.07-1.25) and combined endovascular/surgical treatment (OR 1.24; 1.09-1.40) had the opposite effect. Men (0.64; 0.55-0.74) and diabetics (0.44; 0.55-0.74) were less likely to undergo an AKA whereas patients with coronary (1.28; 1.10-1.47) or cerebrovascular (1.90; 1.33-2.71) disease were more likely to have the procedure. Age, deprivation, hypertension, hypercholesterolemia, smoking and geographical location did not influence the level of amputation.
CONCLUSIONS: When a major leg amputation is necessary, the risk of this being carried out above the knee may be lowest after endovascular revascularization attempts and highest after combined endovascular and surgical treatment.