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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899

Frequency: Bi-Monthly

ISSN 0392-9590

Online ISSN 1827-1839


International Angiology 2015 June;34(3):195-201


Matrix metalloproteinases and peripheral arterial disease

Giagtzidis I. 1, Karkos C. 1, Pitoulias G. 2, Papazoglou K. 1

1 Fifth Surgical Department, Hippokrateio General Hospital, Thessaloniki, Greece;
2 Surgical Department, Georgios Gennimatas General Hospital, Thessaloniki, Greece

It has been postulated that atherosclerosis should be considered as a chronic inflammatory process and peripheral arterial disease (PAD) is a manifestation of such an atherosclerotic vascular disease. Matrix metalloproteinases (MMPs) are significant circulating biomarkers which play a pivotal role in the initiation, progression and clinical manifestations of PAD. This review summarizes the current body of evidence with regard to the association between MMPs and PAD.

language: English


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