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A Journal on Angiology
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
International Angiology 2013 June;32(3):339-48
Automated carotid intima-media thickness and its link for prediction of SYNTAX score in Japanese coronary artery disease patients
Ikeda N. 1, Saba L. 2, Molinari F. 3, Piga M. 2, Meiburger K. M. 3, Sugi K. 1, Porcu M. 2, Bocchiddi L. 2, Acharya U. R. 4, 5, Nakamura M. 1, Nakano M. 6, Nicolaides A. 7, Suri J. S. 8, 9 ✉
1 Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan;
2 Department of Imaging Sciences, Cagliari University Hospital, Polo di Monserrato, University of Cagliari, Monserrato, Cagliari, Italy;
3 Biolab, Department of Electronics and Telecommunications, Turin Politecnico, Turin, Italy;
4 Department of Electronics and Computer Engineering, Ngee Ann Polytechnic University, Singapore;
5 Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia;
6 CVPath Institute Inc., Gaithersburg, MD, USA;
7 Vascular Diagnostic Center, Nicosia, Cyprus;
8 CTO, Diagnostic and Monitoring Division, Athero Point LLC, USA;
9 Biomedical Engineering Department, Idaho State University, Idaho, USA
Aim: The purpose of this study was to evaluate whether the automated carotid intima-media thickness (CIMT) identified by using automated software could predict the SYNTAX score for coronary artery disease (CAD) patients.
Methods: Three-hundred-seventy consecutive patients (males 218; median age 69±11 years) who underwent carotid-ultrasound and coronary angiography were analyzed. Two experienced interventional cardiologists calculated the SYNTAX score from the carotid angiograms. After ultrasonographic examinations were performed, the plaque score (PS) was calculated and automated carotid IMT analysis was obtained by a fully automated algorithm. Correlation and stepwise logistic regression analysis were calculated and also the Receiver Operating Characteristics (ROC) curve analysis was computed.
Results: The mean SYNTAX score was 8.1±14.4; the PS was 7.1±14.4 and the mean CIMT was 0.86±0.23 mm (Normality rejected with a P-value of 0.001). A statistically significant correlation was found between the CIMT and SYNTAX score (r=0.323; P=0.0001) and between the PS and SYNTAX score (r=0.583; P=0.0001). The area under the ROC curve (Az) between CIMT and coronary artery disease was 0.648 (P=0.0001) and the CIMT of 1 mm or more was associated with the presence coronary artery disease with a specificity of 90.5%. Logistic regression analysis confirmed the association between CIMT and SYNTAX score (P=0.0002).
Conclusions: Results of our study using an automated algorithm showed a statistical significant association between CIMT and SYNTAX score and indicated that CIMT may be considered a reliable parameter for prediction of SYNTAX score in Coronary Artery Disease patient population from Japan.