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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2013 June;32(3):327-31

language: English

Progression of coronary artery calcification in asymptomatic individuals with pre-existing calcium score

Koulaouzidis G. 1, 2, Charisopoulou D. 3, Maffrett S. 2, Tighe M. 2, Jenkins P. J. 2, McArthur T. 2

1 Heart Centre and Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden;
2 European Scanning Centre, London, UK; 3Royal Brompton and Harefield NHS Foundation Trust, London, UK


Aim: Coronary artery calcification (CAC) has been introduced as a reliable, non-invasive marker of atherosclerosis. In this retrospective study, we investigated the progression of CAC using electron beam computed tomography.
Methods: The study enrolled 598 individuals (521 males; mean age: 59.3±8.3 years) with initial CAC score (CACS) ≥10. The mean interscan period was 2.4±1.35 years (range: 1-7 years). The mean CACS, for the entire cohort, was 262.4±423.9 at baseline scan and 380.3±547.6 at follow-up. The mean annualized progression in CACS was 57.7±123.7; 47.4±66.5 in females and 58.3±128.1 in males (P=0.46). The mean annualized progression in CACS was 39.6±61.3 in individuals <60 years and 75.7±161.5 in individuals >60 years (P=0.0003). In multivariate analysis, only baseline CACS (P<0.0001) and smoking (P=0.002) were independently associated with the annual change in CACS.

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