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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899

Frequency: Bi-Monthly

ISSN 0392-9590

Online ISSN 1827-1839


International Angiology 2011 February;30(1):12-7


Effect of immersion in CO2-enriched water on free radical release and total antioxidant status in peripheral arterial occlusive disease

Dogliotti G. 1, Galliera E. 1, Iorio E. 2, De Bernardi Di Valserra M. 3, Solimene U. 1,4, Corsi M. M. 1,5

1 Department of Human Morphology and Biomedical Sciences “Città Studi”, University of Milan, Italy;
2 International Observatory for Oxidative Stress, Salerno, Italy;
3 Rabbi Fonti, Trento, Italy;
4 Bioclimatology Study Center, University of Milan, Milan, Italy;
5 Operative Unit of Clinical Pathology, IRCCS Policlinico San Donato, Milan, Italy

AIM: The aim of this paper was to investigate the release of oxygen free radicals in patients with peripheral occlusive arterial disease and the effects of immersion of the legs and feet in carbon dioxide (CO2)-enriched water.
METHODS: Twenty-five patients with peripheral occlusive arterial disease (Fontaine stage II) and 15 healthy controls were treated by immersing the lower legs in either CO2-enriched or normal spa water. Blood samples were collected in heparinized tubes and total antioxidant status (TAS) and reactive oxygen metabolites (ROMs) were measured after five treatments a week for two weeks.
RESULTS: d-ROM plasma levels decreased in patients with peripheral occlusive disease after immersion in CO2-enriched water (P<0.001), and in healthy controls (P<0.01), in line with a significant increase in TAS (P<0.001).
CONCLUSION: CO2-enriched water immersion had a positive effect, reducing free radical plasma levels and raising the levels of antioxidants, suggesting an improvement in the microcirculation.

language: English


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