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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2010 December;29(6):496-506

language: English

IL-6, TNF-alpha, IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions

Stanisic´ M. 1, Majewski W. 1, Zurawski J. 2, Lesniewska K. 3, Majewski P. 2

1 Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland;
2 Department of Clinical Pathomorphology, Poznaƒ University of Medical Sciences, Poznan, Poland;
3 Department of Biology and Environmental Studies, Poznan University of Medical Sciences, Poznan, Poland


AIM: The aim of this study was to assess morphological and immunohistochemical differences in arterial wall inflammation during primary and secondary vascular reconstructions.
METHODS: Forty patients with lower extremities ischemia underwent vascular reconstruction: Group I included patients undergoing primary vascular reconstruction with 25 minor arterial reconstructive procedures; Group II included patients undergoing secondary reconstruction due to limb ischemia after at least 12 months since first operation (15). Immunohystochemical expression of IL-1-BETA,IL-6,and TNF-alpha in arterial wall was correlated with serum concentration.
RESULTS: No differences were observed in IL-1-beta, IL-6, TNF-alpha expression among groups (P=0.06, P=0.13, P=0.9). Cytokines expression was not accompanied by the growth of its serum concentrations (P=0.8, P=0.9). IL-6 serum concentration depended on the degree of limb ischemia and was very high in case of critical limb ischemia (P=0.006). Arterial morphology was comparable among the groups.
CONCLUSION: IL-6, IL-1-BETA, TNF-alpha expression in the arterial wall is comparable in primary and secondary lesions. Serum concentrations of IL-6, IL-1-BETA, TNF-alpha are independent of its arterial wall expression.

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