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Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
Online ISSN 1827-1839
Griffin M. 1, Nicolaides A. 2-5, Tyllis T. 2,5, Georgiou N. 2,5, Martin R. M. 6, Bond D. 1, Panayiotou A. 3, Tziakouri Ch. 7, Dore C. J. 8, Fessas Ch. 9
1 Vascular Screening and Diagnostic Centre, London, UK;
2 The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus;
3 Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus;
4 Department of Vascular Surgery, Imperial College, London, UK;
5 Vascular Screening and Diagnostic Centre, Nicosia, Cyprus;
6 Department of Social Medicine, University of Bristol, Bristol, UK;
7 Department of Radiology, Nicosia General Hospital, Nicosia, Cyprus;
8 MRC Clinical Trials Unit, London, UK:
9 The Cyprus Heart Foundation, Nicosia, Cyprus
AIM:Different ultrasonic arterial wall measurements have been used as predictors of future myocardial infarction or stroke. The aim of the present study was to determine the relationship of total plaque area (TPA) (the sum of the atherosclerotic plaque area measurements from both carotid and both common femoral arteries) with prevalence of cardiovascular disease in a population-based cross-sectional study and compare it with intima-media thickness (IMT).
METHODS: Seven hundred sixty-two individuals (47% male) over the age of 40 were screened for cardiovascular risk factors.
RESULTS: Evidence of clinical cardiovascular disease was present in 113 (14.8%). Both carotid and both common femoral bifurcations were scanned with ultrasound. After adjustment for conventional risk factors the association of IMT with prevalence of clinical cardiovascular disease was low (P=0.84, OR of upper IMT quintile 1.36; 95% CI 0.56 to 3.26) and of TPA high (P<0.001, OR of upper TPA quintile 8.38; 95% CI 2.57 to 27.32). TPA greater than 42 mm2 (cut-point derived from ROC curve analysis) identified 266 (34.9%) of the population that contained 87/113 (76.9%) of the clinical events (sensitivity: 77%; specificity: 73%; positive predictive value: 33%; negative predictive value: 94%; positive likelihood ratio of 2.79). In contrast, IMT greater than 0.07 mm had a sensitivity, specificity, positive and negative predictive value and positive likelihood ratio of 68%, 60%, 23%, 91% and 1.69 respectively.
CONCLUSION: Total plaque area appears to be more strongly associated with the prevalence of cardiovascular disease than IMT. This finding warrants further prospective studies.