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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899

Frequency: Bi-Monthly

ISSN 0392-9590

Online ISSN 1827-1839


International Angiology 2010 April;29(2):176-82

    Original articles

Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study

Malagoni A. M. 1, Galeotti R. 1, Menegatti E. 1, Manfredini F. 1, Basaglia N. 2, Salvi F. 3, Zamboni P. 1

1 Vascular Diseases Center, University of Ferrara, Ferrara, Italy;
2 Department of Rehabilitation Medicine, S. Anna Hospital, Ferrara, Italy;
3 Department of Neurology, Multiple Sclerosis Center, Bellaria Hospital, Bologna, Italy

AIM: Chronic fatigue (CF) severely affects patients with multiple sclerosis (MS), but its pathogenesis remains elusive and the effectiveness of available treatments is modest. We aimed to evaluate the effect on CF of the balloon dilatation of stenosing lesions affecting the main extracranial veins configuring the chronic cerebrospinal venous insufficiency (CCSVI), a condition strongly associated with MS.
METHODS: Thirty-one MS consecutive patients (16 males, age 46.2±9.4 years) with associated CCSVI and CF underwent the endovascular procedure. Fatigue was assessed using the Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS) at baseline (T0) and one (T1), six (T6) and twelve (T12) months after the procedure. In ambulatory patients (N.=28), mobility was evaluated using the 6-min walking test at T0 and T1.
RESULTS: and MFIS scores significantly improved from preoperative values, and the positive trend was maintained at one year (FSS: T0=5.1±1.0 to T12=3.5±1.8, P<0.001; MFIS-total score: T0=34.9±14.8 to T12=22.5±13.7, P<0.001; MFIS-Physical subscale: T0=21.2±8.0 to T12=13.5±9.7 P<0.001; MFIS-Cognitive subscale: T0=9.2±9.5 to T12=6.0±6.3, P=0.03; MFIS-Psychosocial subscale: T0=4.5±2.1 to T12=2.5±2.1, P<0.001). Six-min walking distance (6MWD) at T1 improved significantly (332±190m to 378±200m, P=0.0002). In addition, an inverted correlation between 6MWD and MFIS-physical subscale variations was found in the subgroup of patients (N.=8) with no lower limb motor impairment (r=-0.74, P=0.035).
CONCLUSION: The reestablishment of cerebral venous return dramatically reduced CF perception in a group of MS patients with associated CCSVI, suggesting that CF is likely the symptom of CCSVI.

language: English


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