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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2010 February;29(1):27-9

language: English

Periodontitis and carotid atheroma: is there a causal relationship?

Tzorbatzoglou I. D. 1, Sfyroeras G. S. 2, Giannoukas A. D. 2

1 Department of Vascular Surgery, Red Cross Hospital, Athens, Greece;
2 Department of Vascular Surgery, University of Thessaly Medical School, University Hospital of Larissa,, Mezourlo, Larissa, Greece


Periodontal diseases are highly prevalent in the population. Several studies implicated that chronic periodontitis may affect the arterial wall inducing subclinical atherosclerosis by triggering a systemic inflammatory response. Three theories have been put forward to explain potential mechanisms involved: the theory of bacterial invasion, the cytokine theory and the autoimmunization theory. Periodontal inflammation could have a role in the initiation and progression of arterial diseases such as coronary artery disease and carotid atherosclerosis. Further clinical studies are required to investigate if there is a causal relationship of chronic periodontitis with echolucent unstable carotid plaques.

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giannouk@med.uth.gr, agiannoukas@hotmail.com