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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899

Frequency: Bi-Monthly

ISSN 0392-9590

Online ISSN 1827-1839


International Angiology 2009 June;28(3):202-8


Relationship between insulin-like growth factor-1 system and exercise tolerance in patients with intermittent claudication

Laurenzano E. 1, Brevetti G. 1, Lanero S. 1, Brevetti L. 1, Colao A. 2, Chiariello M. 1

1 Departments of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples “Federico II”, Naples, Italy
2 Department of Molecular and Clinical Endocrinology and Oncology; University of Naples “Federico II”, Naples, Italy

Aim. Insulin-like growth factor-1 (IGF-1) plays an important role in exercise physiology. We aimed the present study at assessing whether IGF-1 system and its changes with exercise are related to walking capacity in intermittent claudication (IC).
Methods. In 45 IC patients, blood samples for the measurement of IGF-1, IGF binding protein-3 (IGFBP-3), and acid labile subunit (ALS) were taken at rest and immediately after a treadmill exercise performed until initial claudication distance (ICD), i.e. until the occurrence of claudication pain in the affected limb. Control group consisted of 45 age- and sex-matched subjects without previous myocardial infarction or stroke.
Results. When IC patients were divided into two groups according to ICD value, ANOVA showed significant group differences for IGFBP-3 and ALS. Indeed, resting levels of IGFBP-3 were 3537±109 mg/L in controls, moderately lower (3399±204 mg/L) in IC patients with ICD≥median, and markedly lower (2580±196 mg/L) in those with ICDConclusion. Impaired IGF-1 system is implicated in the complex mechanism responsible for reduced exercise tolerance in IC. Furthermore, this finding suggests that affected individuals could represent a target population for interventions to rise IGF-1 levels.

language: English


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