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A Journal on Angiology
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2003 September;22(3):243-9
Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld’s phenomenon and workers with vibration-induced white finger
Nakamura H. 1, Matsuzaki I. 2, Hatta K. 3, Nagase H. 4, Nobokuni Y. 1, Kambayashi Y. 1, Ogino K. 1
1 Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa, Japan
2 Institute of Community Medicine, University of Tsukuba, Tsukuba, Japan
3 Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
4 Department of Environmental Health, Toyama Institute of Health, Toyama, Japan
Aim. Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud’s phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated.
Methods. We monitored changes of finger blood flow during cold water (10°C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects.
Results. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers.
Conclusion. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.