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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2002 December;21(4):384-9


language: English

The effect of lipoprotein-a on thrombolytic therapy and spontaneous reperfusion in acute myocardial infarction. A comparative study

Dagdelen S. 1, Eren N. 2, Akdemir I. 2, Karabulut H. 2, Ergelen M. 1, Caglar N. 2

1 Kosuyolu Heart and Research Hospital, Istanbul, Turkey 2 Acibadem Hospital, Istanbul, Turkey


Background. To eval­u­ate the role of serum lip­o­pro­tein-a (Lp-a) lev­els on the suc­cess of throm­bo­lyt­ic ther­a­py (TT) in ­patients with acute myo­car­dial infarc­tion (MI).
Meth­ods. ­Patients: 56 ­patients ran­dom­ly allo­cat­ed into 2 ­groups (A and B) with an approx­i­mate­ly 1 to 2 ratio. Group A con­sist­ed of 18 ­patients who ­received 1,5 mil­lion IU strep­tok­i­nase. Group B: 38 ­patients receiv­ing 100 mg t-PA total­ly and Group C: 22 ­patients who did not ­received any TT as con­trols. All ­patients had under­gone cor­o­nary angio­gra­phy in the first 7 days and the ­degree of TIMI flow was deter­mined in the ­infarct relat­ed ­artery with TIMI-0 and I being con­sid­ered as unsuc­cess­ful per­fu­sion, where­as TIMI-II and III as suc­cess­ful. Lp-a level ≥30 mg/dl was con­sid­ered as high Lp-a level.
­Results. Paten­cy rates were sim­i­lar in Group A and B, in cases with high or low Lp-a lev­els (p>0.05 for both). In Group C paten­cy rate was found sig­nif­i­cant­ly high­er in patients with high Lp-a level com­pared to patients with low Lp-a (p<0.01). Lp-a level in Group C was sim­i­lar with Group A and B (p>0.05). The time inter­val for cor­o­nary angio­gra­phy was sim­i­lar in all ­groups (p>0.05 for all).
Con­clu­sions. Lp-a level does not ­effect the reper­fu­sion out­come of TT in patients with MI. How­ev­er in those patients who not ­received TT, spon­ta­ne­ous reper­fu­sion rate was found sig­nif­i­cant­ly high­er in patients with low Lp-a level com­pared to those with high Lp-a level.

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