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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2002 March;21(1):44-52

language: English

The effect of peripheral vascular disease on the serum levels of natural anti-oxidants: bilirubin and albumin

Krijgsman B., Papadakis J. A. *, Ganotakis E. S. *, Mikhailidis D. P. *, Hamilton G.

From the Department of Surgery and *Department of Molecular Pathology and Clinical Biochemistry at the Royal Free Campus, Royal Free and University College Medical School, University College London, London, UK


Background. Bilirubin and albu­min may act as anti­ox­i­dants. Their cir­cu­lat­ing lev­els are lower in those ­patients with ischem­ic heart dis­ease (IHD) and could be fur­ther ­reduced by more exten­sive ath­ero­scler­o­sis, i.e. periph­er­al vas­cu­lar dis­ease (PVD).
Methods. Serum bilir­u­bin and albu­min were meas­ured in 456 ­patients clas­si­fied into 3 ­groups: 1) no clin­i­cal­ly evi­dent car­di­o­vas­cu­lar dis­ease (CVD), 2) IHD ­present and 3) PVD ­present. Smoking stat­us and gen­der (which ­affect bilir­u­bin and albu­min lev­els in ­healthy indi­vid­u­als) were con­sid­ered sep­ar­ate­ly.
Results. Bilirubin was lower in smok­ing men with­out CVD or with PVD than in non-smok­ers (p=0.02 and p=0.04, respec­tive­ly) in the same ­groups. Non-smok­ing women with­out CVD had sig­nif­i­cant­ly (p=0.004) lower bilir­u­bin lev­els than the cor­re­spond­ing group of men. Frequency anal­y­sis of male non-smok­ers ­revealed sig­nif­i­cant­ly (p=0.04) more ­patients with a lower bilir­u­bin (<6.5 μmol/l) in the PVD com­pared with the no CVD group. Albumin lev­els ­showed the same ­trends.
Conclusions. Prospective stud­ies ­should con­sid­er smok­ing and gen­der when assess­ing the rel­e­vance of bilir­u­bin and/or albu­min lev­els in ­patients with vas­cu­lar dis­ease. Our find­ings sup­port those of other stud­ies that show that low serum bilir­u­bin and albu­min lev­els are asso­ciat­ed with the pres­ence of vas­cu­lar dis­ease.

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