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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2001 September;20(3):195-9


language: English

Fibrinogen, lipoprotein (a) and lipids in patients with erectile dysfunction. A preliminary study

Sullivan M. E., Miller M. A. W. *, Bell C. R. W. *, Jagroop I. A. **, Thompson C. S. **, Khan M. A. ***, Morgan R. J. ***, Mikhailidis D. P. **

From the Department of Urology, Churchill Hospital, Oxford, * Department of Urology, Northampton General Hospital, Northampton, ** Department of Molecular Pathology and Clinical Biochemistry, Royal Free Hospital, London, UK *** Department of Urology, Royal Free Hospital, London


Background. Erectile dysfunction is associated with cardiovascular risk factors (e.g. hypertension, smoking, dyslipidemia and diabetes) and is more common in patients with cardiovascular disease. We therefore assessed the prevalence of two predictors of vascular events, fibrinogen and lipoprotein-a, in patients with and without erectile dysfunction.
Methods. Men with erectile dysfunction (48 non-smokers, 48 smokers), aged 45-70 years, were compared with controls (21 non-smokers, 21 smokers) with normal erectile function and no known pathology.
Results. Serum total cholesterol was significantly higher in non-smokers with erectile dysfunction compared to both control non-smokers and erectile dysfunction smokers. Men with erectile dysfunction who smoked had a significantly higher plasma fibrinogen level than control smokers. Similarly, men with erectile dysfunction, who did not smoke had higher levels of plasma fibrinogen compared to both smokers and non-smokers without erectile dysfunction. No significant difference in serum lipoprotein-a values was found.
Conclusions. These findings support the concept that cardiovascular risk factors are predictors of erectile dysfunction and that this may be another manifestation of vascular disease.

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