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Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
Online ISSN 1827-1839
Rittoo D., Cramb R. *, Odogwu S., Khaira H., Duddy M. **, Smith S., Vohra R.
From the Department of Vascular Surgery, * Department of Biochemistry, ** Department of Radiology, Selly Oak Hospital, University Hospital Birmingham NHS Trust, Selly Oak, Birmingham, United Kingdom
Background. To determine if uncontrolled hypercholesterolaemia predisposes to progression of carotid artery stenosis.
Methods. Fasting blood samples were collected from 76 patients referred for carotid duplex ultrasound for investigation of transient ischaemic attacks or recent stroke. Patients were grouped depending on the severity of the stenosis found. Patients on lipid lowering agents were excluded. The data were analysed using one way analysis of variance and the χ2 test as appropriate.
Results. There were more men in the 70-99% group (15 vs 6, χ2=10.6, p<0.001, Table I). The total cholesterol was raised in all three groups. Patients with carotid stenosis of 70-99% had significantly elevated triglycerides (2.4 mmol vs 1.47 mmol and 1.37 mmol, p<0.003), low HDL (1.14 mmol vs 1.45 mmol and 1.18 mmol, p<0.003) and a higher cholesterol/HDL ratio (5.56 vs 4.29 and 4.71, p<0.014) compared with the other two groups. There was no difference in lipoprotein(a) in the three groups.
Conclusions. Increased triglycerides and low HDL cholesterol seen in the 70-99% group suggest that a worsening lipid profile is associated with progression of carotid artery stenosis.