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Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
Online ISSN 1827-1839
Kurz X., Kahn S. R. 1, Abenhaim L. 1, Clement D. 2, Norgren L. 3, Baccaglini U. 4, Berardi A. 1, Cooke J. P. 5, Cornu-Thenard A. 6, Depairon M. 7, Dormandy J. A. 8, Durand-Zaleski I. 9, Fowkes G. R. 10, Lamping D. L. 11, Paartsch H. 12, Scurr J. H. 13, Zuccarelli F. 14
From the Department of Pharmacology, University of Liege, Belgium;
1 Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada;
2 Department of Cardiovascular Diseases, Ghent University Hospital, Belgium;
3 Department of Surgery, Lund University, Sweden;
4 Clinic of Surgery I, Padua Research University, Italy;
5 Section of Vascular Medicine, Stanford University School of Medicine, Stanford, USA;
6 Department of Cardiology, Saint-Antoine Hospital, Paris, France;
7 Department of Internal Medicine, Division of Cardiology, Vaud University Hospital, Lausanne, Switzerland;
8 Department of Surgery, St.-George’s Hospital, London, UK;
9 Department of Public Health, Henri-Mondor Hospital, Paris, France;
10 Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, University of Edinburgh, UK;
11 Health Services Research Unit, London School of Hygiene and Tropical Medicine, UK;
12 Department of Dermatology, Wilhelmina’s Hospital, Vienna, Austria;
13 The Middlesex Hospital, University College and Middlesex School of Medicine, London, UK;
14 Department of Angiology-Phlebology, Saint-Michel Hospital, Paris, France
Background. To critically review the classification, epidemiology, outcomes, diagnosis and treatment of chronic venous disorders of the leg (CVDL), to issue evidence-based recommendations, and to identify areas requiring further research.
Methods. Articles identified by an extensive literature search were scored by members of an international task force. Only those articles with a moderate or strong rating for internal validity were retained.
Results. A scoring system weighing CVDL severity according to the probability of ulcer occurrence is proposed. Epidemiological data on the frequency of CVDL and its risk factors are reviewed. The following items are evaluated: costs associated with treatment; clinical outcomes related to CVDL and its treatment; available generic and disease-specific measures of quality of life; diagnostic procedures used to detect venous reflux; and efficacy of available treatments.
Conclusions. CVDL is an important public health problem, based on its prevalence, cost and impact on quality of life. High-priority areas for research on CVDL are identified.