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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 1999 March;18(1):70-3


language: English

Sleep apnoea syndrome and the extent of atherosclerotic lesions in middle-aged men with myocardial infarction

Aboyans V., Lacroix Ph., Virot P. *, Tapie Ph. **, Cassat C. *, Rambaud G. *, Laskar M., Bensaid J. *

From the Department of Thoracic and Cardiovascular Surgery and Angiology * Department of Cardiology, ** Sleep Laboratory, Dupuytren’s University Hospital, Limoges, France


Background. To deter­mine wheth­er extend­ed ath­e­ros­cle­rot­ic ­lesions are cor­re­lat­ed to the pres­ence of sleep breath­ing dis­or­ders.
Methods. Experimental ­design: A pros­pec­tive clin­i­cal study. Setting: A ter­tiary region­al ref­er­ral cen­ter. Patients: 40 male ­patients ≤65 years con­sec­u­tive­ly admit­ted to the car­diac care unit for an acute myo­car­dial infarc­tion with ser­ous crea­tinine phos­phok­i­nase (CPK) ≥350 IU/l and a CPK-MB frac­tion ≥10%. Exclusion cri­te­ria were: car­diac sur­gery on emer­gen­cy, ­stroke, major neu­ro­log­i­cal and/or psy­chi­at­ric dis­tur­banc­es, alco­hol con­sump­tion >50 g/day, tox­i­co­ma­nia, clin­i­cal or bio­log­i­cal hypo­thy­roid­ism, clin­i­cal acrom­e­gal­y and chron­ic obstruc­tive pul­mo­nary dis­ease. Measures: Duplex ultra­so­nog­ra­phy was per­formed on carot­id arter­ies, femo­ral arter­ies and their bifur­ca­tions. An over­night poly­som­nog­ra­phy was per­formed after hos­pi­tal dis­charge. Patients with an apnoa index > 5/hour or apnoea-hypop­nea index >10/hour of sleep are con­sid­ered to have sleep apnoea syn­drome (SAS). Patients with addi­tive periph­er­al ath­e­ros­cle­rot­ic ­lesions are com­pared to ­patients with nor­mal carot­id and femo­ral arter­ies, regard­ing to stan­dard car­di­o­vas­cu­lar risk fac­tors and apnoe­as or hypop­noe­as dur­ing sleep.
Results. Duplex ­revealed in 18 ­patients carot­id and/or femo­ral ath­e­ros­cle­rot­ic ­lesions. The prev­a­lence of SAS in ­patients with at least one periph­er­al arte­ri­al ­lesion was sig­nif­i­cant­ly high­er (61% vs 18%, p<0.01). A near­ly sig­nif­i­cant dif­fer­ence was also noted in ­patients with carot­id ­lesions alone com­par­ed to those with nor­mal carot­id arter­ies (57% vs 27%, p=0.06).
Conclusions. These ­results sug­gest a pos­sible link ­between sleep breath­ing dis­or­ders and the path­o­gen­e­sis of ath­e­ros­cle­rot­ic ­lesions.

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