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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 1999 March;18(1):65-9

language: English

Thrombocytosis after pro­phy­lac­tic admin­is­tra­tion of enox­ap­ar­in: unexpected find­ings in a ­Polish pros­pec­tive mul­ti­cen­ter trial on the effi­ca­cy and safe­ty of enox­ap­ar­in in the pre­ven­tion of post­op­er­a­tive throm­boem­bo­lism

Ziaja K., Simka M., Krupowies A., Dugaj M., Ludyga T.

From the First Department of General & Vascular Surgery, Silesian Medical Academy, Katowice, Poland


Background. Heparin-relat­ed throm­bo­cy­to­pe­nia is a com­mon com­pli­ca­tion of hep­ar­in admin­is­tra­tion and there­fore plate­let count was mon­i­tored in our study.
Methods. Experimental ­design: Prospective mul­ti­cen­tre study. Setting: 14 Departments of General, Thoracic or Ortho-pedic Surgery, Poland. Patients: 290 ­patients—150 gen­er­al or tho­rac­ic sur­gery ­patients aged above 40 years, and 140 ortho­pae­dic sur­gery ­patients aged ­between 18 and 60 years. Interventions: All ­patients ­received 20 mg (gen­er­al and tho­rac­ic sur­gery) or 40 mg of enox­ap­ar­in (ortho­pae­dic sur­gery) once daily sub­cu­ta­ne­ous­ly both ­before sur­gery and dur­ing post­op­er­a­tive immo­bil­isa­tion. Measures: Platelet count was eval­u­at­ed prior to sur­gery and on the 5th, 7th, 11th and 15th day fol­low­ing the oper­a­tion.
Results. There was nei­ther throm­bo­cy­to­pe­nia nor hep­ar­in-­induced throm­bo­sis. Paradoxically, post­op­er­a­tive plate­let count in most cases ­increased slight­ly but sta­tis­ti­cal­ly sig­nif­i­cant­ly, but in some how­ev­er, even above 600 G/l, nev­er­the­less in these ­patients no throm­bot­ic com­pli­ca­tions ­occurred. Postoperative throm­bo­cy­to­sis was great­er in ­patients with neo­plasms as well as those with exces­sive per­i­op­er­a­tive blood loss and trans­fu­sions.
Conclusions. As plate­let count was not the main topic of our study, the pre­sent­ed data ­should be regard­ed only as pre­lim­i­nary. Further inves­ti­ga­tions to ­resolve the cause of the ­observed phe­nom­e­non of throm­bo­cy­to­sis are there­fore nec­es­sary.

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