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A Journal on Angiology

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 1998 December;17(4):276-81


language: English

Decreased beta2 adrenergic mediated venodilatation in Native Americans

Vajo Z., Cruz E., Szekacs B., Dachman W.

From the Department of Medicine, Maricopa Medical Center, Phoenix, Arizona, USA and the * 2nd Department of Medicine, Semmelweis University, Budapest, Hungary


Background. A con­sid­er­able body of ­research has been accu­mu­lat­ed regard­ing the path­o­gen­e­sis and treat­ment of hyper­ten­sion in Whites (Caucasians) and in Blacks. This ­research has led to more effec­tive ther­a­pies ­geared spe­cif­i­cal­ly ­towards these eth­nic ­groups. Unfor-tunately, very lit­tle infor­ma­tion is avail­able regard­ing the path­o­gen­e­sis of hyper­ten­sion and the ­effect of anti­hy­per­ten­sive treat­ment in Native Americans (North-American Indians). Ethnic var­i­abil­ity in the ­response to adre­ner­gic medi­at­ed stim­u­la­tion has been pre­vi­ous­ly ­described, and ­reduced com­pli­ance of the ­venous ­system has been sug­gest­ed among the pos­sible mech­a­nisms respon­sible for essen­tial hyper­ten­sion. The aim of this study was to com­pare ­venous respon­sive­ness ­between Native Americans and Whites to vasoac­tive sub­stanc­es.
Methods. The α1-adre­ner­gic ago­nist, phen­y­leph­rine and the β2-adre­ner­gic ago­nist iso­pro­ter­e­nol were stud­ied in 10 Native American and White vol­un­teers. The dor­sal hand vein tech­nique was used, which is a sim­ple, rel­a­tive­ly non-inva­sive meth­od to study the ­response to vasoac­tive sub­stanc­es, in vivo.
Results. The max­i­mal ven­o­dil­a­to­ry ­response to iso­pro­ter­e­nol in the Native American group was 53.2±27.5%; while in the White group it was 103.4±66.0% (p<0.05). The max­i­mal venoc­on­stric­tion for phen­y­leph­rine in the Native American sub­ject group was sim­i­lar to that of the White group (85.4±24.0% vs 89.4±10.9%) (p=n.s.).
Conclusions. Based on our find­ings, we can antic­i­pate that Native Americans may ­respond dif­fer­ent­ly to anti­hy­per­ten­sive ther­a­py. However, fur­ther inves­ti­ga­tion needs to be done with an eye ­towards the devel­op­ment of drug ther­a­py and treat­ment strat­e­gies tail­ored to this spe­cif­ic pop­u­la­tion.

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