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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Giuseppe MUSUMECI 1, Francesca M. TROVATO 2, Marta A. SZYCHLINSKA 1, Soraya SCUDERI 1, Federica FIDONE 2, Rosa IMBESI 1, Paola CASTROGIOVANNI 1
1 Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, Italy; 2 Department of Clinical and Experimental Medicine, Internal Medicine Division, School of Medicine, University of Catania, Catania, Italy
Phyllodes tumors (PT) of the breast are rare fibroephitelial neoplasms. Malignant phyllodes tumor (MPT) usually presents rapid growth and it is difficult to distinguish it from a pure sarcoma. We report a rare case of diagnosed MPT in which we performed immunohistochemistry (IHC) for heparin-binding EGF-like growth factor (HB-EGF) considering that HB-EGF IHC was already used in other studies as a possible target of cancer in other pathologies. A 43-year-old patient presented, at physical examination, a palpable mass on the left breast with accentuated vascularization and increased growth in the last four months. The diagnosis was made through various examination such as mammogram, breast ultrasound, color-Doppler, PET, histopathological analysis and the HB-EGF IHC. Macroscopy evidenced a trilobulated lesion, measuring 9x7x7cm, and the anatomopathologic analysis confirmed the diagnosis of MPT. A strong cytoplasmic HB-EGF immunolabeling was evident. IHC is a very specific technique often able to differentiate such tumors. In the present case report IHC has evidenced the expression of HB-EGF, suggesting further investigation in order to consider HB-EGF as a possible marker in the diagnosis of MPT.