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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2016 May;175(5):195-204
Influences of I/D polymorphism of ACE1 gene on effects of combined exercise on physical fitness and health-related parameters in middle-aged women
Byung Y. KANG, Jaekoo LEE
Research Institue for Behavior, Fitness and Medicine, Sahmyook University, Seoul, Korea
BACKGROUND: The purpose of this study was to investigate the influence of the insertion/deletion (I/D) polymorphism in the angiotensin converting enzyme 1(ACE1) gene on physical fitness and health-related parameters in response to combined exercise program.
METHODS: A total of 60 middle-aged women were participated in this study, and they carried out combined exercise program for 12 weeks, 3 days a week, 60 minutes per day. The I/D polymorphism in the ACE1 gene was analyzed by direct polymerase chain reaction (PCR) amplification and 2% agarose gel electrophoresis.
RESULTS: Although this genetic polymorphism was not significantly associated with any physical fitness factors or health-related parameters at baseline or in response to combined exercise program, there was statistically significant difference between genotypes and baseline power value of the subjects (P<0.05).
CONCLUSIONS: We conclude that the I/D polymorphism in the ACE1 gene may be one of the useful genetic marker for baseline power as a physical fitness factor in middle-aged women.